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Focused symposium: Physical rehabilitation in critical care and beyond: bringing trials to the bedside

Chair: Marike van der Schaaf (Netherlands)
Speakers: Sabrina Eggmann (Switzerland), Hajime Katsukawa (Japan), Anastasia Newman (Canada)

Learning objectives
  1. Understand the global challenge of limited access to evidence-based rehabilitation following critical illness by focusing on recent evidence from clinical trials and variations in control groups across the globe.
  2. Evaluate quality assurance considerations related to appropriate dosage and safe implementation of physical rehabilitation interventions in critical care.
  3. Identify practical strategies for the implementation of physical rehabilitation in critical care and beyond in diverse healthcare settings.

Abstract

Survivors of critical illness commonly face long-term physical, mental, cognitive, and social health complications, known as Post Intensive Care Syndrome (PICS). It can occur during prolonged admissions in the intensive care unit (ICU) and can last for years after hospital discharge. Yet, specific rehabilitation pathways for affected persons are lacking across the globe. The coronavirus pandemic has further exacerbated an already strained healthcare system with personnel shortages and limited resources. This leaves countless patients after a critical illness without access to physical rehabilitation. Moreover, uptake of evidence-based rehabilitation interventions remains low, despite recent high-quality evidence that physical rehabilitation reduces ICU and hospital length of stay, improves physical function and cognitive outcomes, and empowers patients in their recovery. Reasons for the poor implementation include recent trials presenting inconclusive findings regarding the effectiveness of physical rehabilitation, with some even indicating the potential for increased risk of both adverse events and mortality. This has led to uncertainty across the globe. Additionally, systematic reviews have shown methodological inconsistencies, poor intervention reporting and a large variation in usual care practices across the globe that complicate interpretation and implementation in clinical practice. Accordingly, the aims of this seminar are to highlight the impact of personalised physical rehabilitation on long-term health outcomes and how to apply it in clinical practice. Particularly, we will consider the consequences of heterogeneity in control group reporting and how even small changes can influence local clinical practice. We will explore the diversity and suitability of physical rehabilitation interventions ranging from passive movement to robotic devices and functional exercises such as sitting or walking. By critically reviewing the evidence, we will discuss the challenge of finding an optimal and safe dosage and recommend on an optimal and personalised approach for each patient across their trajectory of recovery. Participants of this seminar will learn how to balance physical activity and rest by using continuous monitoring of cardiorespiratory parameters and by learning to recognise signs of patient exhaustion. We will highlight how to collaborate with other healthcare professionals to provide personalised and functional physical rehabilitation and give practical tips for family involvement and patient participation to improve early outcomes and ultimately enhance recovery. Finally, we will provide clinicians at the bedside with practical recommendations from experienced physiotherapists working across the globe using evidence-based strategies such as mobilization protocols to maximize intervention frequency, and targeted goal-setting.  

 

In summary, by critically examining methodological inconsistencies and exploring practical strategies for an optimal and safe dosage, this symposium seeks to enhance the relevance and applicability of research findings in diverse healthcare settings, ultimately advancing physical rehabilitation after critical illness worldwide.

References
  1. van der Schaaf M et al. Postintensive care syndrome, need for recognition, treatment, research, and expansion of included symptoms. Crit Care Med. 2012 Sep;40(9):2742-3; author reply 2743. doi: 10.1097/CCM.0b013e31825ae849. 
  2. Farley C, Newman ANL, Hoogenes J, Brooks D, Duffet M, Kho ME. Treatment fidelity in 94 randomized controlled trials of physical rehabilitation in the ICU: A scoping review. Critical Care Medicine 2024; 52 (00). 
  3. TEAM Trial Investigators. Early Active Mobilization during Mechanical Ventilation in the ICU. New England Journal of Medicine 2022; 387: 1747-1758.  
  4. Paton M et al. Association of active mobilization variables with adverse events and mortality in patients requiring mechanical ventilation in the intensive care unit: a systematic review and meta-analysis. Lancet Respiratory Medicine 2024.  
  5. Eggmann S, Irincheeva I, Luder G, Verra ML, Moser A, Bastiaenen CHG, Jakob SM. Cardiorespiratory response to early rehabilitation in critically ill adults: A secondary analysis of a randomised controlled trial. PLoS One. 2022 Feb 3;17(2):e0262779. doi: 10.1371/journal.pone.0262779. 
  6. Katsukawa H et al. Risk Factors of Patient-Related Safety Events during Active Mobilization for Intubated Patients in Intensive Care Units-A Multi-Center Retrospective Observational Study. J Clin Med. 2021;10:2607. doi: 10.3390/jcm10122607. 
  7. Kwakman RCH, van der Schaaf M et al. Steps to recovery: Body weight-supported treadmill training for critically ill patients: A randomized controlled trial. J Crit Care. 2022 Jun;69:154000. doi: 10.1016/j.jcrc.2022.154000. 
  8. Major ME, Dettling D, Ramaekers SPJ, Engelbert RHH, van der Schaaf M. Feasibility of a home-based interdisciplinary rehabilitation program for patients with Post-Intensive Care Syndrome: the REACH study. Crit Care. 2021 Aug 5;25(1):279. doi: 10.1186/s13054-021-03709-z. 
  9. Eggmann S et al. We need to talk about adverse events during physical rehabilitation in critical care trials. EClinicalMedicine. 2024 Feb 1;68:102439. doi: 10.1016/j.eclinm.2024.102439. 
  10. Kwakman RCH, van der Schaaf M et al. Metabolic load during morning care and active bed exercises in critically ill patients: An explorative study. Aust Crit Care. 2023 Jun 5:S1036-7314(23)00061-9. doi: 10.1016/j.aucc.2023.04.006.
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